Acquired Weakness in Critically Ill Patients

Publish Date: 23 - 25 June 2009
Author(s): Gerald Supinski, MD

Abstract:

Critically ill patients often face the peculiar challenge of both skeletal and respiratory muscle wasting. The cause of lean body mass loss is multi-factorial and this loss results in the activation of several cellular pathways. This presentation investigates the mechanisms responsible for increased protein degradation and decreased protein synthesis. By understanding this process, better therapies can be developed that decrease the morbidity from acquired weakness.
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Author Bios

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Gerald Supinski, MD

University of Kentucky, Lexington, Kentucky
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