The 110th Abbott Nutrition
Research Conference
June 23-25, 2009
Columbus, Ohio
The Role of Nutrition in Accretion:
Retention and Recovery of Lean Body Mass
The purpose of this conference is to explore the underlying nutrition mechanisms controlling muscle quality and quantity. For the purpose of this conference, "nutrition" can be broadly defined as macronutrients, micronutrients, components, and metabolites of food, and exercise should always be included. Everyone is aware of the health consequences of excess fat, but we believe that insufficient skeletal muscle mass also contributes to morbidity and loss of functionality.
John Morley, MD, St. Louis University, St. Louis, Missouri
Topic: Skeletal Muscle Physiology and Nutrition Parameters
Regulation of Muscle Protein Synthesis and Degradation in Normal and Pathophysiological States
Denis Guttridge, PhD, The Ohio State University, Columbus, OhioIn normal muscle, hypertrophy and atrophy balance one another. When homeostasis is disrupted, and atrophy becomes the dominant response, conditions such as muscular dystrophy, cachexia and pediatric rhabdomyosarcoma can aris. This presentation explores the role of the Akt/mammalian target of rapamycin (mTOR) pathway in hypertrophy and the FoxO and NF-kB transcription factors in atrophy.
Read Full Presentation.
Effects of Nutrition on Muscle Metabolism
Michael Tisdale, PhD, Aston University, Birmingham, United KingdomMechanisms Underlying Changes in Function of Aging Skeletal MusclesIan Lanza, PhD, Mayo Clinic, Rochester, MinnesotaMuscle fatigability, the ability to sustain muscle activity for a prolonged period, is less recognized than muscle wastin, but is an important factor in decreasing muscle function of agin skeletal muscle. Understanding and intervening in the mechanisms that cause decline can perhaps slow the aging process, thus increasing physical function and teh ability to perform activities of daily living. This presentation investigates these mechanisms.
Read Full Presentation.
Role of Oxidative Stress in Skeletal Muscle and Strength
Mike Reid, PhD, University of Kentucky, Lexington, Kentucky, US
Discussion: Skeletal Muscle Physiology and Nutrition Parameters
Moderator: Jeffrey Baxter, PhD, Abbott Nutrition
Topic: Skeletal Mass Retention during Adulthood: Influence of Nutrition and Exercise on LBM and Functionality
Role of Protein Absorption and Nutrient Timing on Muscle Mass Accretion
Stuart Phillips, PhD, McMaster University, Hamilton, OntarioImpact of Nutrition on Lean Body Mass and Exercise Recovery in Athletes
Jeff Volek, PhD, RD, University of Connecticut, Storrs, Connecticut
Role of Vitamin D in Muscle Strength and Function
Michael Holic, PhD, MD, Boston University, Boston, Massachusetts, USDiscussion: Skeletal Mass Retention During Adulthood.
Moderator: Christine Steele, PhD, Abbott NutritionTopic: Sarcopenia of Aging: Impact of Nutrition and ExerciseChallenges of Defining Sarcopenia: Status Report of the EUGMS Working Group on Sarcopenia
Tommy Cederholm, MD, PhD, Uppsala University, Uppsala, SwedenNutrition, Muscle Mass, and Muscular Performance in Middle Age and Beyond Catherine Johnson, PhD, RD, LD, Abbott NutritionLean Body Mass Loss With Age Douglas Paddon-Jones, PhD, University of Texas, Galveston, TexasEffects of Unloading in Old Versus Young Humans
Charlotte Suetta, MD, PhD, Institue of Sports Medicine and Centre of Healthy Aging, Bispebjerg Hospital, Copenhagen, Denmark
Discussion: Sarcopenia of Aging: Impact of Nutrition and Exercise
Moderator: Tracy Smith, PhD, RD, LD, Abbott NutritionPanel Discussion
Moderator: Neile Edens, PhD, Abbott NutritionTopic: Effects of Metabolic Stress on Leand Body MassThe Cachexia Associated with COPD
Annemie Schols, PhD, University Hospitals, Maastricht, NetherlandsMeasurement of Lean Body Mass Using CT Scans Vickie Baracos, PhD, University of Alberta, CanadaAcquired Weakness in Critically Ill Patients
Gerald Supinski, MD, University of Kentucky, Lexington, KentuckyCachexia in Cancer
Ingvar Bosaeus, MD, Sahlgrenska University Hospital, Goteborg, Sweden
The metabolic events surrounding cachexia in cancer differ greatly from those in starvation, with muscle loss reflecting the former and fat loss reflecting the latter. Stand-alone nutritionintervention is unlikely to prevent the development of cachexia as it will restore only body fat. Therefore, special focus should be paid to understanding and intervening in the catabolic events leading to muscle loss. This presentation discusses the most effective strategies to block catabolism, and thereby increase survival, function,and quality of life in cancer patients. Read Full Presentation.
Discussion: Effects of Metabolic Stress on Leand Body Mass
Moderator: Anne Coble Voss, PhD, RD, LD, Abbott Nutrition
Structured Panel Discussions
Moderator: Neile Edens, PhD, Abbott Nutrition