The 110th Abbott Nutrition Research Conference

June 23-25, 2009,
Columbus, Ohio
Acquired Weakness in Critically Ill Patients

Gerald Supinski, MD, University of Kentucky, Lexington, Kentucky
Critically ill patients often face the peculiar challenge of both skeletal and respiratory muscle wasting.  The cause of lean body mass loss is multi-factorial and this loss results in the activtion of several cellular pathways.  This presentation investigates the mechanisms responsible for increased protein degradation and decreased protein synthesis.  By understanding this process, better therapies can be developed that decrease the morbidity from acquired weakness.

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