People are living longer than ever before and therefore are more likely to experience age-related diseases and conditions. However, living longer is not matched by an increase in healthy life expectancy. The aging population demographics is having a dramatic impact on dementia incidence worldwide, with prevalence approximately doubling every 20 years and estimated to increase to 115 million by 2050. Dr. Minihane discusses the overlap that exists between the pathophysiology of cardiovascular disease and cognitive decline (eg, dyslipidemia, vascular stiffness, and insulin insensitivity association with increased risk of Alzheimer’s disease). She also reviews the acute and chronic impact of eicosapentaenoic acid and docosahexaenoic acid and the interaction with the apolipoprotein 4 (APOE-ε4) genotype.
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