The Cachexia Associated with COPD

Publish Date: 23 - 25 June 2009
Author(s): Annemie Schols, PhD


Recent research shows that COPD is not only a chronic inflammatory lung disease but also a metabolic disorder affecting multi-organ systems. Weight loss, skeletal muscle wasting, and a decreased muscle oxidative phenotype are well documented in advanced COPD and have been a target for multimodal intervention strategies. Promising results have been obtained by existing strategies that include exercise and nutritional supplementation with or without anabolic agents. This article describes advances in understanding the molecular mechanisms of altered muscle plasticity in COPD progression, providing new leads for nutritional intervention.
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Author Bios

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Annemie Schols, PhD

University Hospitals, Maastricht, Netherlands

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