Regulation of Muscle Protein Synthesis and Degradation in Normal and Pathophysiological States

Publish Date: 23 - 25 June 2009
Author(s): Denis Guttridge, PhD

Abstract:

In normal muscle, hypertrophy and atrophy balance one another. When homeostasis is disrupted, and atrophy becomes the dominant response, conditions such as muscular dystrophy, cachexia and pediatric rhabdomyosarcoma can aris. This presentation explores the role of the Akt/mammalian target of rapamycin (mTOR) pathway in hypertrophy and the FoxO and NF-kB transcription factors in atrophy.
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Author Bios

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Denis Guttridge, PhD

The Ohio State University, Columbus, Ohio
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