Role of Oxidative Stress in Skeletal Muscle and Strength

Publish Date: 23 - 25 June 2009
Author(s): Mike Reid, PhD

Abstract:

Current research indicates that reactive oxygen species (ROS) production by muscle fibers is increased in a variety of physiological and pathophysiological conditions, including chronic inflammation, aging, mechanical unloading, and strenuous exercise. Increases in intracellular ROS activity can promote muscle weakness and fatigue via two parallel pathways. This paper describes these pathways and suggests that they appear to be regulated independently and can have separate or additive effects on mechanical function.
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Author Bios

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Mike Reid, PhD

University of Kentucky, Lexington, Kentucky, US
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