PROBIOTICS & PRETERM INFANTS: A POSITION PAPER BY ESPGHAN
ESPGHAN Committee on Nutrition and the ESPGHAN Working Group for Probiotics and Prebiotics
The European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) is a multi-professional organization whose aim is to promote the health of children through knowledge creation and the dissemination of science-based information.
This position paper includes a conditional recommendation for the use of the probiotic blend of Bifidobacterium lactis (BB-12), Bifidobacterium infantis (BB-02), and Streptococcus thermophilus (TH-4) when each of the strains were administered at a dose of 3.0 to 3.5 x 108 cfu/g.
The review assessed clinical outcomes in preterm infants. Recommendations were based primarily on the results from RCTs and the RCTs needed to meet requirements for sample size and statistical power to detect differences in clinical outcomes. The clinical outcomes evaluated in the trials met the meta-analysis criteria.
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